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Purpose-built Chyme
Reinfusion Therapies
for intestinal failure
and rehabilitation

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Insides System - fistuloclysis, distal feeding, best, alternative to parenteral nutrition, fistula, ostomy, ileostomy, chyme, enteral, oral nutrition, enteromate, intestinal failure, colon cancer, bowel cancer, gut cancer, ostomy appliance, high output, chyme, dehydration, defunctioned, ileus, lars, microbiome, lower interior resection syndrome, incontinent, incontinence, gut health, reversal surgery

For adult intestinal
failure and rehabilitation

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Insides Neo- fistuloclysis, distal feeding, best, alternative to parenteral nutrition, fistula, ostomy, ileostomy, chyme, enteral, oral nutrition, enteromate, intestinal failure, colon cancer, bowel cancer, gut cancer, ostomy appliance, high output, chyme, dehydration, defunctioned, ileus, lars, microbiome, lower interior resection syndrome, incontinent, incontinence, gut health, reversal surgery

For pediatric intestinal
failure and rehabilitation

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Clinical and Economic Benefits
1. Picot et al., (2017) Chyme reinfusion in patients with intestinal failure due to temporary double enterostomy: A 15-year prospective cohort in a referral centre (Clin Nutr)
6. Layec S, Seynhaeve E, Trivin F, Carsin-Mahé M, Dussaulx L, Picot D. Management of entero-atmospheric fistulas by chyme reinfusion: A retrospective study. Clin Nutr [Internet]. 2020 Apr; Available from: https://linkinghub.elsevier.com/retrieve/pii/
S0261561420301485
5. Dilke, S. M., Gould, L., Yao, M., Souvatzi, M., Stearns, A., Ignjatovic-Wilson, A., Tozer, P., & Vaizey, C. J. (2021). Distal feeding–bowel stimulation to treat short-term or long-term pathology: a systematic review. Frontline Gastroenterology, 12(7), 677–682. https://doi.org/10.1136/flgastro-2019-101359
4. Fielding A, Woods R, Moosvi SR, Wharton RQ, Speakman CTM, Kapur S, et al. Renal impairment after ileostomy formation: a frequent event with long‐term consequences. Color Dis [Internet]. 2019 Oct 17;codi.14866. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1
111/codi.14866
3. Layec et al., (2020) Management of entero-atmospheric fistulas by chyme reinfusion: A retrospective study (Clin Nutr)
2. Klek et al., (2016) Management of acute intestinal failure: A position paper from the European Society for Clinical Nutrition and Metabolism (ESPEN)

Reduced loss of enteric contents

Reduced volume of chyme discarded

Return to Oral Feeding1

91% weaned off parenteral nutrition to oral feeding within a median of two days

Restoration of Gut function2

Reverse gut atrophy and inflammation

Patient can mobilise

Untethered to IV pole

Patient Nutritional Status1

Improved Nutritional Risk Index by 10.9

Significant Economic Savings

Cost savings from reduction in parenteral nutrition and reduced length of stay in hospital

Reduced Intestinal losses1

85% reduction in intestinal losses with increased length of bowel available for absorption

Earlier discharge

Once chyme reinfusion therapy is established, patient able to rehabilitate at home

Improved Liver function3

Reduction in liver abnormalities with continued use

Reduced loss of enteric contents

Reduced volume of chyme discarded

Return to Oral Feeding1

91% weaned off parenteral nutrition to oral feeding within a median of two days

Restoration of Gut function2

Reverse gut atrophy and inflammation

Patient can mobilise

Untethered to IV pole

Patient Nutritional Status1

Improved Nutritional Risk Index by 10.9

Improved Liver function3

Reduction in liver abnormalities with continued use

Earlier discharge

Once chyme reinfusion therapy is established, patient able to rehabilitate at home

Reduced Intestinal losses1

85% reduction in intestinal losses with increased length of bowel available for absorption

Significant Economic Savings

Cost savings from reduction in parenteral nutrition and reduced length of stay in hospital

Ian Bissett discussing The Insides System and fistuloclysis, distal feeding, best, alternative to parenteral nutrition, fistula, ostomy, ileostomy, chyme, enteral, oral nutrition, enteromate, intestinal failure, colon cancer, bowel cancer, gut cancer, ostomy appliance, high output, chyme, dehydration, defunctioned, ileus, lars, microbiome, lower interior resection syndrome, incontinent, incontinence, gut health, reversal surgery

Professor Ian Bissett
Co-Founder & Chief Medical Officer

“Encourage the formation of double stomas and the consideration of the use of the distal opening for reinfusion of chyme in the setting of an enteroatmospheric fistula.”

fistuloclysis
distal feeding
best
alternative to parenteral nutrition
fistula
ostomy
ileostomy
chyme
enteral
oral nutrition
enteromate
intestinal failure
colon cancer
bowel cancer
gut cancer
ostomy appliance
high output
chyme
dehydration
defunctioned
ileus
lars
microbiome
lower interior resection syndrome
incontinent
gut health
reversal surgery
Succus Entericus
intestinal juice
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Portugal

Caution:Investigational device. Limited by United States law to investigational use.